C.O.P.D is a Systematic Inflamation Disease

The present review aims to demonstrate that chronic obstructive pulmonary disease (COPD) is not a chronic inflammatory disease of the lung but concerns the entire body. We refer to the inflammatory cells circulating in the blood, the relationship between c-reactive protein (CRP) and the forced expiratory volume in the first second of the most violent exhalation (FEV-1), and the mechanisms that trigger chronic inflammation in other systems such as the cardiovascular, musculoskeletal, etc. 

It therefore follows that COPD is a chronic inflammatory disease of the lungs and the body in general and should be treated as such.

Smoking and inhalation of other pollutants are certainly responsible for the onset of inflammation, first in the lungs and then in other organ systems.